http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101031550-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f874eb11d4775decc4fd06a6071a4c9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 |
| filingDate | 2005-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afddfc2348d1e8584384dbf36f1c0d36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0895f6a73b865e27a992183ecfa5c63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66d39409fd5a22b97ccb07b70d5a7031 |
| publicationDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101031550-B |
| titleOfInvention | 5-carbocyclic- or heterocyclic-substituted pyrimidines that inhibit HIV |
| abstract | A class of HIV replication inhibitors having formula (I) and its N-oxide, a class of pharmaceutically acceptable addition salts, a class of quaternary amines or a class of stereochemical isomers thereof, wherein -a 1 =a 2 -a 3 =a 4 -is -CH =CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N-, -N=N-CH=CH-; -b 1 =b 2 -b 3 =b 4 -is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N -, -N=N-CH=CH-; R 1 is hydrogen; aryl; formyl; C 1-6 alkylcarbonyl; optionally substituted C 1-6 alkyl; C 1-6 alkoxycarbonyl; R 2 is hydroxyl; halo; optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; substituted carboxyl; carbonyl; CN; nitro; amino; substituted amino; polyhalogen Methyl; polyhalomethylthio; S(=O) rR6 ; S(=O) rR6 ; R2a is cyano; amino; substituted amino; optionally substituted C1-6 alkyl; halo Base; optionally substituted C 1-6 alkoxy, substituted carboxyl; -CH=N-NH-C(=O)-R 16 ; optionally substituted C 1-6 alkoxy C 1-6 alkyl; Substituted C 2-6 alkenyl or C 2-6 alkynyl; -C(=NOR 8 )-C 1-4 alkyl; R 7 or -X 3 -R 7 ; X 1 is -NR 1 -,- O-, -C(=O)-, CH 2 , -CHOH-, -S-, -S(=O)r-; R 3 is cyano; amino; C 1-6 alkyl; halo; any Substituted C 1-6 alkoxy; Substituted carboxyl; -CH=N-NH-C(=O)-R 16 ; Substituted C 1-6 alkyl; Optionally substituted C 1-6 alkoxy C 1-6 alkyl; substituted C 2-6 alkenyl or C 2-6 alkynyl; -C(=NOR 8 )-C 1-4 alkyl; R 7 ; -X 3 -R 7 ; R 4 is Halo; Hydroxy; Optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; C 3-7 cycloalkyl; C 1-6 alkoxy; CN; Nitro; Polyhalogen C 1-6 alkyl; Polyhalogen C 1-6 alkoxy; Substituted carboxyl; Formyl; Amino; Mono- or two (C 1-4 alkyl) amino or R 7 ; R 5 is -YC q H2 q -L or -C q H 2q -YC r H 2r -L; L is aryl or Het; methods for preparing these compounds, including methods for preparing pharmaceutical components with these compounds as active ingredients, and These compounds are used to prevent or treat HIV infection. |
| priorityDate | 2004-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.