| abstract |
The present invention provides a compound represented by the formula (I), which has antiviral activity, especially HIV integrase inhibitory activity, a pharmaceutically acceptable salt of the compound, or a solvate of either; and a medicine, especially an anti-HIV drug, which contains the compound, salt, or solvate. (In the formula, Y is NR<4> (R<4> is hydrogen, etc.), O, S, SO, or SO<2>; R<A> is (1) a group represented by the formula -COR<5> (R<5> is a group selected among substituents (A)) or (2) a group represented by the formula wherein ring C is an optionally substituted, nitrogenous aromatic heterocycle in which at least one of the atoms adjacent to the atom having a bond for external linkage is an unsubstituted nitrogen atom; and the broken line indicates the presence or absence of a bond); R<1> is hydrogen, etc.; X is a single bond, etc.; R<2> is a group selected among substituents (A); and R<3> is hydrogen, etc.; provided that the substituents (A) are hydrogen, hydroxy, optionally substituted lower alkyls, etc. |