| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K23-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K23-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate |
2003-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d55f1d382a1deb3cafca00e0cee692b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5232f38558dfd5aa7a1226328b4d192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a77cae71c90f0077d0e9df576693ddb7 |
| publicationDate |
2010-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-100594885-C |
| titleOfInvention |
Process for the preparation of crystalline nano-particle dispersions |
| abstract |
A process for the preparation of a dispersion of crystalline nano-particles in an aqueous medium is disclosed, wherein the process comprises combining (i) a first solution comprising a substantially water-insoluble substance in a water-miscible organic solvent with; (ii) an aqueous phase comprising water and optionally a stabiliser, to form a dispersion of amorphous particles; and (iii) sonicatingthe dispersion of amorphous particles for a sufficient period to form crystalline nano-particles of the substantially water-insoluble substance. The process provides nano-crystals with a mean hydrodynamic diameter of less than 1 micron, particularly less than 300 nm and is particularly useful for the preparation of nano-crystalline dispersions of pharmaceutical substances. |
| priorityDate |
2002-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |