http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100591652-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 |
| filingDate | 2005-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7a48d6aeceb7bb9bc88b0a9b2bb9a1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c47b98852cff9d2acbe0ea507b068b0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9c155614f93551b1f478b0582f9ca6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ae95084ed2d868f21a29987aa499f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d358cf581bc6ee3df000d0e0d6e8790 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3180c651208a3e410bcfa0b5dc4359a8 |
| publicationDate | 2010-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-100591652-C |
| titleOfInvention | Method for producing 2-(4-fluoro-benzyl)-phenyl-acetic acid |
| abstract | The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis (2- 15 methoxyethoxy) aluminate (Red-Al) to the corresponding alcohol ; d) chlorinat ing the alcohol obtained in step c) ; e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2) : f1) reacting the product obtained in step d) with sodium cyanide ; f2) hydro lysing the product obtained in step f1). The present invention provides a process for the production of [2-(4-fluoro-benzyl)- phenyl]-acetic acid which is suitable for industrial scale reactors (e.g. which is cleaner and more efficient). Also, [2-(4-fluoro-benzyl)-phenyl]-acetic acid is obtained as a crystalline material with a purity > 95%. |
| priorityDate | 2004-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.