| abstract |
The present invention relates to a compound formula (I): wherein (II) is (III) or (IV), X is bond, -CH2-, -O- or -NH-, R<1> and R<12> are each independently hydrogen, halogen, lower alkyl, etc., R<2> is hydrogen or optionally substituted lower alkyl, R<3> is hydrogen or an amino protective group, R<4>, R<5> and R<6> are each independently hydrogen or optionally substituted lower alkyl, R<7> is -Z-R<13>, in which Z is bond, etc., and R<13> is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl) carbamoyl or lower alkanoylsulfamoyl, R<8> is -Y-R<9>, in which Y is bond, -CH2-, -O-, -S-, etc., and R<9> is hydrogen, lower alkyl, cyclo (lower) alkyl, etc., and R<11> is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence. |