http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100540005-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8be6a6c990669567cc455d32b00535e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5383 |
| filingDate | 2004-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-100540005-C |
| titleOfInvention | Trinucleated 1-[(3-indol-3-yl as the cannabinoid CB 1 receptor agonist) carbonyl] bridged piperazine derivatives |
| abstract | The present invention relates to the to have general formula trinucleated 1-[(indol-3-yl of (I)) carbonyl] bridged piperazine derivatives: formula I wherein X be CHn 2 , O or S; R represents 1-3 substituent group, and it is independently selected from H, (Cn 1-4 ) alkyl, (Cn 1-4 ) alkoxyl and halogen; Rn 1 Be (Cn 5-8 ) cycloalkyl; Rn 2 Be H or (Cn 1-4 ) alkyl; Rn 3 , Rn 3 ', Rn 4 ' Rn 4 ', Rn 5 , Rn 5 ' and Rn 6 ' be hydrogen or (C independentlyn 1-4 ) alkyl, the latter is randomly by (Cn 1-4 ) alkoxyl, OH or halogen replace; Rn 6 Be hydrogen or (Cn 1-4 ) alkyl, the latter is randomly by (Cn 1-4 ) alkoxyl, OH or halogen replace; Or Rn 6 And Rn 7 Form the saturated heterocycle of 4-7 unit together, it randomly contains other hetero atom that is selected from O and S; Rn 7 And Rn 6 Form the saturated heterocycle of 4-7 unit together, it randomly contains other hetero atom that is selected from O and S; Or Rn 7 Be H, (Cn 1-4 ) alkyl or (Cn 3-5 ) cycloalkyl, alkyl is randomly by OH, halogen or (Cn 1-4 ) the alkoxyl replacement; Or its pharmaceutically acceptable salt.The invention still further relates to pharmaceutical composition, it comprises described trinucleated 1-[(indol-3-yl) carbonyl] bridged piperazine derivatives, and relate to these derivants in the application of treatment in the pain, peri-operation period pain for example, chronic pain, neuropathic pain, cancerous pain is with pain and the spasm relevant with multiple sclerosis. |
| priorityDate | 2003-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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