| abstract |
A novel pyrimidine compound having an excellent antagonistic activity against adenosine receptors A1, A2A, and A2B receptors. Specifically, it is a compound represented by the following formula, a salt of the compound, or a solvate of either. I In the formula, R1 and R2 are the same or different and each represents hydrogen, optionally substituted C1-6 alkyl, etc. R3 represents hydrogen, halogeno, etc. R4 represents an optionally substituted C6-14 aromatic hydrocarbon ring group, optionally substituted 5- to 14-membered nonaromatic heterocyclic group having at least one unsaturated bond, etc. and R5 represents an optionally substituted C6-14 aromatic hydrocarbon ring group or optionally substituted 5- to 14-membered aromatic heterocyclic group. |