| abstract |
Hydrophilic semi-permeable hollow fibre membrane for treating blood, having an integrally asymmetrical structure based on a synthetic polymer. The hollow fibre membrane comprises a separation layer on the inner surface thereof and an open-pored supporting layer which is adjacent thereto, in addition to an ultrafiltration rate in an albumen solution of 5 - 25 ml/(h<.> m<2.>mmHg). The hollow fibre membrane is devoid of pore-stabilising additional substances and has a sieving coefficient for albumen of a maximum of 0.005, and a sieving coefficient for cytochrome C, where for the ratio is SKcc >= 5<.>10<-5.>UFRAlb<3> - 0,004<.>UFRAlb<2> + 1,081<.>UFRAlb -0,25. The invention also relates to a method for the production of said type of membranes according to a non-soluably induced coagulation process, wherein a spinning solution is extruded from a synthetic first polymer and, optionally, a hydrophilic second polymer by means of the annular gap of a hollow fibre nozzle in order to form a hollow fibre and at the same time, a coagulation medium as an inner filling through the central opening of the hollow fibre nozzle, said medium triggering the coagulation inside the hollow fibre. A separation layer is embodied on the inner side of the hollow fibre and the membrane structure. The method is characterised in that the inner filling contains a polyelectrolyte having negative charges. |