| abstract |
The present invention discloses a prodrug which comprises long chain fatty acyl and substitutes venlafaxine. The prodrug comprises a compound of which the structure is disclosed in a general formula 1, and a medicinal salt or aqua compound, wherein R1 represents hydrogen, straight chain or branch chain alkyl, or acyl or trifluoromethyl containing 1 to 6 carbon; R2 represents straight chain or branch chain carbon acyl containing 8 to 18 carbon; star represents a chiral center. The present invention also discloses a preparation method of the prodrug and the application of the prodrug for preventing and curing central nervous system diseases. The half life of the prodrug provided by the present invention approaches to or exceeds 10 hours. Compared with venlafaxine, the prodrug has the advantage of excellent long-acting effects. |