abstract |
The invention relates to a compound or salt thereof represented by the following formula (I): (wherein, W represents W<A>-A<1>-W<B>-(in which W<A> is substituted or unsubstituted aryl etc.); A<1> is -NR<1>-, single bond, -C(O)-, etc., and W<B> is substituted or unsubstituted arlene, etc.), R is a single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O)-,-CH2-, etc., and M is a group represented by the following formula (iii), for example: (in which, R<11>, R<12> and R<13> independently represent hydrogen, hydroxyl, amino, halogen, etc., R<14> is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A<2> is a single bond, etc, and R<10> is hydroxyl or lower alkoxy). The compound or salt thereof selectively inhibits binding of cell adhesion molecules and VAL-4 and exhibits high oral administration absorbability, which is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like. |