| abstract |
The present invention relates to a substituted dioxopentacyclic derivative which is provided with a formula (I) with a neurotrophy function, or pharmaceutical salts of the substituted dioxopentacyclic derivative or hydrates of the substituted dioxopentacyclic derivative, and the definition of each group in the formula (I) is disclosed in the specification. The present invention also relates to medicinal compositions of the compounds, and the medical application of the medicinal compositions which are used as an FK506 combination proteinase activity inhibitor for preparing, preventing or treating neurodegenerative diseases and other nervous disorder diseases caused by nerve damage or relevant diseases. |