| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3992843c4d5174abb81c866b7d3b1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c31e3112aee4bc758ef66c16b2ae9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be3140e506d2f3300c16d79f2b5444d3 |
| publicationDate |
2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CL-2020002742-A1 |
| titleOfInvention |
Process for preparing (4s) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by separation of racemate by ester of diastereomeric tartaric acid |
| abstract |
The present invention relates to a new and improved process for the preparation of (4S) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6 -naphthyridine-3-carboxamide of formula (I) and preparation of enantiomer (Ia) by racemate separation with chirally substituted tartaric acid esters of general formulas (IIIa) and (IIIb), where Ar is an aromatic compound or substituted or unsubstituted heteroaromatic. |
| priorityDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |