abstract |
A method for preparing a (S) -5- (R 2) -N- (2-hydroxy-2-methylpropyl) -4- (2-methylpyrrolidine-1-carbonyl) thiazole-2-carboxamide comprising the reaction step (S ) -N- (2-hydroxy-2-methylpropyl) -4- (2-methylpyrrolidine-1-carbonyl) thiazole-2-carboxamjda, R 2 -Br, K2CO3, Pivalic acid, Pd2 (dba) 3.CHCI3 and cataCXium A, where R2 is selected from the group. |