| abstract |
<p> The present invention relates in general to compositions and methods for treating cancer and neoplastic disease. Compounds derived from substituted pyrido [3,4-d] pyrimidin-4-one and pharmaceutical ompositions comprising said compounds are provided herein. The subject compounds and compositions are useful for histone demethylase inhibition. Additionally, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and / or melanoma and the like. </p> |