abstract |
PROCEDURE FOR THE STEROSELECTIVE PREPARATION OF PRIMARY AMINES STEROIDS OF CONFIGURATION AOB IN POSITION 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 OR 17 ON THE STEROID SKELETON, IN WHICH AN OXIMATE OF FORMULA (II ) WITH LITHIUM METALLIC IN LIQUID AMMONIA, AT A TEMPERATURE OF -33 ° C TO -90 ° C, IN A MIXTURE OF SOLVENT OF THE ETHER TYPE AND AN ALIPHATIC ALCOHOL, TO OBTAIN THE FORMULA COMPOUND (1), IN WHICH AMINE CONFIGURATION OF AOB IS IN THE POSITION CORRESPONDING TO THE POSITION OF OXIMA ON THE COMPOUND OF FORMULA (II) AND WHERE THE R, R1, AND R2 RADICALS ARE DEFINED IN THE CLAIMS DOCUMENT. |