http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-661930-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfc91c967e885ba5b44b7ad5278367f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1984-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809aab0fd208ab21f92dc76740617a34 |
| publicationDate | 1987-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-661930-A5 |
| titleOfInvention | Process for the preparation of 17-esters of clobetasol |
| abstract | The invention relates to an improved process for the preparation of 17-esters of clobetasol, which comprises treating 9ss,11ss-epoxy-16ss-methylpregna-1,4-diene-17,21-diol-3,20-dione 17-esters with mesyl chloride to give the corresponding 21-mesylate derivative, using lithium chloride for substituting the mesyloxy group to give the corresponding 21-chloro derivative, followed by opening of the epoxide group with hydrofluoric acid. The invention also relates to novel 17-esters of 21-chloro-9ss,11ss-epoxy-17-hydroxy-16ss-methylpregna-1,4-diene-3-20-dion es, which can be used as intermediates for the preparation of therapeutically active 9 alpha -halogeno-11ss-hydroxy derivatives as well as novel 17-esters of clobetasol. <IMAGE> |
| priorityDate | 1983-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.