http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-638224-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6512 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6512 |
| filingDate | 1978-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59969670519ca8cbbb501447a1863806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56a6c87efb4f18942f82fa36c80886c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_580281055e7632ae32a18a2908748e41 |
| publicationDate | 1983-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-638224-A5 |
| titleOfInvention | Process for the preparation of thiophosphoric acid esters |
| abstract | The invention relates to an improved process for the preparation of dialkoxythiophosphoric acid esters, from substituted hydroxypyrimidines, of the general formula <IMAGE> in which R1 denotes lower alkyl, lower alkenyl, lower alkoxy-lower alkyl or lower alkylthio-lower alkyl, R2 denotes hydrogen, lower alkyl or lower alkenyl and R3 and R4 denote lower alkyl by reacting a thiophosphoric acid dialkyl ester halide of the formula <IMAGE> in which Hal denotes chlorine or bromine and R3 and R4 have the meaning given above with a hydroxypyrimidine of the formula <IMAGE> in which R1 and R2 have the meaning given above. The essential feature of the process comprises converting the hydroxypyrimidine, in the presence of an organic solvent which is capable of forming an azeotrope with water, by reaction with aqueous sodium hydroxide solution into the sodium salt, separating off the water present in the reaction mixture by azeotropic distillation, and reacting the resulting anhydrous sodium salt of the hydroxypyrimidine with the thiophosphoric acid dialkyl ester halide at a temperature from room temperature to 100 DEG C. The procedure according to the invention very largely avoids the formation of unwanted by-products having a cholinesterase-inhibiting action. The dialkoxythiophosphoric acid esters of the above formula, especially O,O-diethyl -O-(2-isopropyl-4-methyl-6-pyrimidyl) thiophosphate, possess an insecticidal and acaricidal action and are therefore suitable for pest control. |
| priorityDate | 1978-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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