| abstract |
The invention relates to compounds of the formula: <IMAGE> their salts and pharmaceutical preparations containing them. In the above formula, R<1> denotes thiadiazolyl or isothiazolyl, R<2> denotes hydrogen or lower alkyl, R<3> denotes carboxyl or esterified carboxyl, R<4> denotes hydrogen, acyloxy, or a heterocyclic ring which is bound via a thio group, and R<5> denotes hydrogen or lower alkoxy. The compounds, and, in particular, among these the syn isomers, in which syn denotes the arrangement with regard to the acid amide group, are notable for a strong antibacterial effect. They can be used for treating infectious diseases in humans and animals. |