http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-626087-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_450181974d9b4a269c53509ac49369f4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1979-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15c38ed6b490a852affcddbbfb61d001 |
| publicationDate | 1981-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-626087-A5 |
| titleOfInvention | Process for the preparation of a syn isomer or a mixture of syn and anti isomers of 7beta-acylamidoceph-3-em-4-carboxylic acids with antibiotic activity |
| abstract | Syn isomers or mixtures of syn and antiisomers (with a syn isomer content of at least 90%) of 7 beta -acylamidoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I in which R is furyl, thienyl or phenyl; R<a> is C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C3 -C7-cycloalkyl or phenyl; R<s> is C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C3 -C7-cycloalkyl, benzyl or phenyl; and B is >S or >S->O are prepared by reacting a corresponding 7-amino compound, where appropriate with intermediate protection of the 4-carboxyl group, with an acid of the formula IV or with an amide-forming derivative thereof; the acid has the syn configuration indicated for formula I. Resulting 1-sulphoxides of the formula I can be reduced to the corresponding 1-sulphides; likewise, resulting ceph-2-em compounds can be isomerised to the corresponding ceph-3-em compounds. The compounds of the formula I can also be esterified. The products are distinguished by a broad spectrum of antibiotic activity in conjunction with a high stability to beta -lactamase and by good stability in vivo. <IMAGE> |
| priorityDate | 1974-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.