| abstract |
Process for the preparation of 3-aminocrotonylazetidinone compounds of the formula <IMAGE> in which R@ denotes hydrogen or an amino protective group R@, R@ represents hydrogen or an acyl group Ac, or R@ and R@ together denotes a bivalent amino protective group, R@ denotes a radical which, together with the carbonyl group -C(=O)-, forms a protected carboxyl group, while the group -N(R@(R@) represents a secondary or tertiary amino group and Y denotes a leaving group, characterised in that a compound of the formula <IMAGE> in which R@, R@, R@ and Y have the abovementioned meanings, or a sulphonic ester of this compound, of the formula <IMAGE> in which R@, R@, R@ and Y have the abovementioned meanings and R5 represents an optionally substituted, in particular aliphatic, cycloaliphatic, araliphatic or aromatic hydrocarbon radical having up to 18 carbon atoms, is treated with a primary or secondary amine of the formula HN(R@)(R@) or a salt thereof. These novel compounds can be used as intermediates for the preparation of 3-cephem compounds. |