| abstract |
D-Homosteroids of the formula <IMAGE> in which R<6> is hydrogen, fluorine, chlorine or methyl; R<9> is chlorine or bromine; R<11> is ( alpha -H, beta -fluoro) or ( alpha -H, beta -chloro) R<17a> is hydroxyl or acyloxy and R<20> is hydrogen, lower alkyl, halo-lower-alkyl, hydroxy-lower-alkyl, acyloxy-lower-alkyl or lower alkoxycarbonyl-lower-alkyl, and the dotted 1,2 bond is an optional C-C bond, are prepared by treatment of a corresponding DELTA <9(11)>-D-homosteroid with Cl2, ClF, BrF or BrCl. The compounds have an endocrine, in particular corticoid-like action. |