| abstract |
Phenoxypropylamine derivatives of the accompanying formula I, in which R denotes hydrogen or alkyl and R1 denotes hydrogen, alkyl, cycloalkyl, aralkyl or aryl or the two together denote a divalent hydrocarbon radical having 4 - 7 C atoms in the main chain, in which one or two of these C atoms can be replaced by oxygen, sulphur or nitrogen, R2 denotes hydrogen, alkyl, aralkyl or aryl, R3 denotes a branched alkyl radical, hydroxyalkyl, cycloalkyl or cyanoalkyl and R4 denotes hydrogen, lower alkyl or aralkyl, or their pharmaceutically tolerable acid addition salts are prepared by reaction of compounds of the accompanying formula II, in which R5 denotes hydrogen or the group <IMAGE> and X denotes the group <IMAGE> or <IMAGE>, where Hal is chlorine, bromine or iodine, with amines of the formula H2N.R3. If R5 in the starting product is hydrogen, the ureido group is then formed by N-acylation. The compounds have a blocking effect on beta -receptors. <IMAGE> |