| abstract |
Novel compounds are prepared which inhibit histamine release and have the general formula I and their salts R1-Ph-X-CnH2n-R2 (I> in which R1 is a tri- or tetracycloaliphatic hydrocarbon radical, R2 is an optionally esterified or amidated carboxyl group, Ph is an optionally substituted phenylene, X is an oxy, thio, sulphinyl or sulphonyl group, and CnH2n is a straight-chain or branched alkylene radical in which n represents the numbers from 1 to 20. Preparation is carried out by reacting a compound of the formula II R1-Ph-X-CnH2n-Z (II> in which Z is an alkali metal or a group -MgHal, with carbon dioxide or an ester, ester halide or amide halide of carbonic acid or a salt thereof. |