| abstract |
Cephalosporin derivs. of formula (I), their non-toxic salts and RYCO=acyl of the aliphatic, carbocyclic aromatic, heterocyclic aromatic contng. 1 or 2 heteroatoms, araliphatic or cyclo-aliphatic series, having a total at wt. is not < 120 when R is carbocyclic aromatic and m=n=0 Y=CH2 or CO; n,m=0 or 1. R'=1-4C alkyl opt. substd. by COOH carbalkoxy or SH. Esp. 7-thienylacetamido cpds. As antibacterial agents; some are active orally. (1) By acylation of a 7-amino cpd. (2) From a 7-acylamino-3-(CH2P) cpd. where P=gp. replaceable by SR', SOR' or SO2R' followed if necessary by oxidn. on the S atom. |