| abstract |
Prodn. of new phenyl-alkenones of formula (I) comprises reacting acid halides (V) with an organometallic methylating agent in an inert solvent under anhydrous conditions, then hydrolysing. In the formula, R is H, F, Cl, Br; R is 1-3C alkyl; Y is Br, I, isobutyl, tert. butyl, cyclohexyl, cyclohexenyl, R2-substd. phenyl or NR3R4; R2 is H, F, Cl, Br or 1-4C alkoxy, R3 and R4 are each 1-3C alkyl or together are (CH2)4, (CH2)5, (CH2)2O(CH2)2, CH2CH=CHCH2 or CH2CH2 NR5CH2CH2; R5 is H or 1-3C alkyl, and X=Cl or Br.(I) are antiinflammatories useful at doses of 70-1500 mg, pref. in 2-4 divided doses or in sustained release formulations. |