http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-589668-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04 |
| filingDate | 1973-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-589668-A5 |
| titleOfInvention | Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde |
| abstract | Novel 4'-Demethyl-1-0- 4,6-O-(3-thenylidene)-beta-D-glucopyranosyl epip- odophyllotoxin of formula (I): is prepared by reacting 4'-demethyle-pipodophyllotoxin-beta-D-glucopyranoside (II) with 3-thiopehecarboxaldehyde of formula (III) or its lower acetals in the presence of a catalyst. Typically, (III) in the form of its dimethylacetal is reacted with (II) in inert, dry solvent in the presence of pref. sulphonic acids. Lewis acids or dried cation-exchange resins with sulphonic acid groups in he H+ form as catalyst. (I) has cystostaic activity and has immunosuppressive properties for humoral as well as cell-bound immunity reactions. (I) inhibits the formation of antibodies and sensibilised cells and may therefore be used for the suppression of undesirable immune reactions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE35524-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3826562-A1 |
| priorityDate | 1973-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.