http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-589075-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2fc4ce3e9075e04472c234519557b46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 |
| filingDate | 1972-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-589075-A5 |
| titleOfInvention | 3-(2-dialkylaminoethyl)-4-alkyl-7-(ethoxycarbonylmethoxy)-coumari- n - prepn - from resorcinol and alpha-alkanoyl-gamma-butyrolactone |
| abstract | Cpds. of formula (I): (where R1, R2 and R3 are 1-3C alkyl), and their hydrohalides, are prepd. by reacting resorcinol with an alpha-R1CO-gamma-butyrolactone and a hydrogen halide in an anhydrous mixt. of a lower aliphatic acid (pref. glacial acetic) and H3PO3 to give a cpd. (II) of formula: (I); -CH2COOEt is H and -NR2R3 is X, in which X is Cl or Br ; reacting this with XCH2COOEt in acetone in the presence of an alkali metal carbonate and a catalyst, pref. DMF or H2O + KI, to give the ethoxycarbonylmethyl ether; reacting this with excess R2R3NH in benzene or toluene in the presence of an acid binder; washing the reaction mixt. with H2O; evaporating; dissolving in EtOH; treating with anhydrous ZnCl2 to form a complex; separating the complex; and decomposing with aq. alkali metal carbonate or NH4OH. Cpds. (I) are medicaments used for treating circulatory disorders. The overall yield is ca. 75%. |
| priorityDate | 1972-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.