http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-575415-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 1972-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-575415-A5 |
| titleOfInvention | Vincamine and apovincamine synthesis - via novel inters |
| abstract | 3-Ethyl-3-formyl-N-(2-(3-indolyl)-ethyl)-2-piperidone is treated with a cpd. of the formula (CH3O)2P(O)-CH(OR)-COOCH3 (where R is lower alkyl) in the presence of a basic condensn. agent, the resulting cpd is subjected to Bischler-Napieralski cyclization and then catalytically reduced, followed by acidic cleavage, the resulting mixture of optically active or racemic vincamine (I) and apovincamine II is sepd. in a conventional manner, and (II) being opt. treated with hydrogen halide at 0 degrees C, the reaction product hydrolysed, and resulting (I) isolated in a conventional manner. (I) has vasodilating, hypotensive and sedative props. |
| priorityDate | 1972-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.