http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-564019-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e45efeaa6a34dfd9d44fa29a7fe0c806 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-10 |
| filingDate | 1972-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-564019-A5 |
| titleOfInvention | 8-aminoalkyl-3-oxo-1-thio-4,8-diazaspiro-decanes - - as liver protecting agents |
| abstract | Compds. (I) (where X is S, SO, SO2 or O: R1 and R2 are H, alkyl cycloalkyl, aryl, aralkyl, alkylfuryl, pyridyl or alkyl- are H, alkyl or aryl; R5 is H, alkyl, aryl, aralkyl, alkylfuryl or pyridyl, R is 1-4C alkylene and n is 0 or 1 and alkyl is a group contg. 1-4C) are prepd. either by introducing the gp. R1R2N-alk or R1R2N- into an appropriate 8-unsubstd. 8-alkyl-substd. 4,8-diazaspirodecane or by forming the spiro ring system from a 4-piperidone HX-CR3R4(CH2)nCOOH and R5NH2 (where X' is O or S). Thus (I X=S, n=0, R3R4=H, R5= m-trifluoromethylphenyl, alk is CH2CH2 and R1=R2=Me) is prepd. from 4-m-trifluoromethylphenyl 3-oxo-1-thio-4,8-diazaspiro 4,5 decane and 2-dimethylaminoethyl chloride. |
| priorityDate | 1972-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.