http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-561739-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12cedce8d26d81271038993ba4912fe6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J19-00 |
| filingDate | 1967-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-561739-A5 |
| titleOfInvention | 4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents |
| abstract | Cpds. (I) X = H, Cl or Br and St = an estrone or androstane residue, linked via C17, and pref. chosen from II-V. R' = H, (1-4C) alkyl, (5-6C) cycloalkyl, or acyl R2 = or =O R3 = H or Me R4 = or =O R5 = or =O R6 = H, lower alkanoyl or a hexoside or hexosyl residue Y = H, OH, or lower alkanoyloxy Z = H or OH Cardiotonics, anti-inflammatories, hypocholesterolemics, and mineralocorticoids. N-Bromosuccinimide (5.05 g.), was added portionwise to a soln. of 17-(3'-furyl)-3-methoxy-estra-1,3,5(10)-triene-17-ol(5.0 g.; prepd. as in US.3,271,392), in dioxan (250 ml.) and H2O (20 ml), stirred 30 mins., dild. (H2O), and extra. (Et2O). The extract was washed (NaHCO3 soln. and H2O), dried, and evapd., giving the 2-subst. 4-bromo-4-hydroxy-2-butenic acid lactone contng. some 4-hydroxy-2-butenic acid lactone. This (67 g.) in HOAc (335 ml.), was stirred 1 h. at 20 deg. with Zn (33.5 g.), filtered, dild. with H2O (3 l.), filtered, and chromat. on SiO2, eluting with PhH-Et2O, and recrystallizing from CH2Cl2-MeOH, giving I(X=H), m.p.172-4 deg. |
| priorityDate | 1966-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.