| abstract |
Analgesic benzazocines of formula (I) where m = 1 or 2, R1 = 1.0 alkyl, and R2 = 1.alkyl, are prepd. by an improved process in which a substd. benzoic acid. (II) is esterified, the ester reduced e.g. with LiAlH4, the resultant, alcohol halogenated and the halide converted to the dinitrile (III). This is then reductively cyclised to give (I). |