http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-544764-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C243-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-16 |
| filingDate | 1971-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1cf4f1b3cede118a4416cf9ac1dba09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10b793cba9a5d0dcccf581f2b06cda1d |
| publicationDate | 1974-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-544764-A |
| titleOfInvention | Process for the preparation of new triazolo-benzodiazepine derivatives |
| abstract | Cpds of formula (I): (where Q is NR2R3;R1 is H or 1-3C alkyl, R2 and R3 are H, 1-6C alkyl, 2-6C hydroxyalkyl or 7-9C aralkyl, or NR2R3 is 5- to 7- membered polymethyleneimino or morpholino, both opt. substd by lower alkyl and contg. =10C; A is 1-3C alkylene, rings B and C are opt substd by F,Cl,Br,CF3,NO2,1-6C alkyl or alkoxy) and their 5-oxides and acid addn salts are CNS depressants. They may be prepd. by reacting a reactive ester of (I;Q=OH) with R2R3NH or its alkali metal deriv; reacting a 2-X-3-R1-5-Ph-3H-1,4-benzodiazepine with R2R3NACONHNH2 (where X=SH lower alkoxy or alkylthio (opt. activated by a substd) or opt. substd amino); hydrolysis of (I;Q=R2R3'N) (where R3'=acyl) to give (I;Q=R2HN); reaction of (I;Q=phthalimido) with N2H4 and/or strong acid to give (I;Q=NH2); redn of (I;Q=N3) to give (I;Q=NH2); or reaction of (IfQ=R2HN) with a 1-6C satd aliphatic oxo cpd and reducing the product. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2709842-A1 |
| priorityDate | 1971-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.