| abstract |
Cpds. of general formulae I and II, and intermediates of general formula III - where - A = H or one or more of the following:- halogen, lower alkyl, -CF3, OH, Oalkyl, O-lower acyl, in any positions but pref. 7 and 8. - B = a pyridine nucleus residue - U = a monovalent residue contng. an amino group at least 2C atoms distant from the tricyclic nucleus e.g. 3- or 4-piperidyl, or -X-NR'R2 - V = a divalent residue contng. an amino group at least 2C atoms distant from the tricyclic nucleus, e.g. 3- or 4-piperidylidene, or =Y-NR'R2 - W = H or OH - R' and R2 independently = H or lower alkyl, or together with the N atom, C atoms and not more than one other N or O, form a 5 or 6 membered hetero cyclic ring. - X and Y = (2-9C) hydrocarbon residues - Antihistamines, antiseratonins, antianaphylactics. Dose 0.1-15 mg./kg./day. - I and II-4 aza cpds. and II (V=piperidylidene) are partic. active antihistamines. - II (V= =CH.CH2CH2NMe2) are C.N.S. active cpds. I and II-3 aza cpds. are antihypertensives. |