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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-20
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20
filingDate 1970-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab5fdd4e016e9d94aab0cab8cc618a11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7384b728968843451657d1da274fbb99
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publicationDate 1973-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CH-537946-A
titleOfInvention Process for the preparation of new derivatives of 7-aminocephalosporanic acid
abstract Therapeutically active cpds. (I) (where R1 is an esp. p- or m- opt. lower alkyl-substd. aminopyridinium gp. and R2 is H or a free or carboxylic acid-esterified OH gp., in which the ester-O atoms may be substd. by S, or an opt. N-substd. carbamoyloxy gp., e.g. -O-CO-NHR3 where R3 is esp. lower alkyl opt. substd. by one or more Cl atoms, or a thiocarbamoylmercapto gp) are prepd. by acylating cpds. (II) with the R1CH2CO gp. (I) have anti-bacterial activity against gram +ve and -ve bacteria, e.g. penicillin-resistant Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Salmonella typhosa and are useful in pharmaceutical compsns, food additives, food preservatives and disinfectants. Pref. (I) where R2 is acetoxy are converted to OH-cpds. which may be reacted with an isocyanate ester to form (I) where R2 is an N-substd. carbamoyloxy gp.
priorityDate 1970-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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