http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-533081-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_671fe6324d50c733d601ccffea4a7bbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_063b5f812db8db830f48461b456d5c90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-06 |
| filingDate | 1967-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b867882c52261a2e4abdff8e885df74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e20cb6b704a92ce70d9c7ecab67fe8fd |
| publicationDate | 1973-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-533081-A |
| titleOfInvention | Process for the production of new organic salts of D-glucosamine |
| abstract | (A) Cpds. (I) R = H, COOH, COOX, CONH2, or CHO X is an alkali-metal or alkaline-earth metal n = 0-3, but if n=0 R is not H m = 1 or, if R = COOH, 2. (B) Method for preparing cpds. (I). An insoluble silver salt of the alpha-keto-acid is suspended in water, and an equivalent amt. of a hydrohalide of D-glucosamine is added in aqs. soln. The mixture is heated, the silver halide is filtered off, and the cpd. (I) is obtd. from the soln. Cpds. (I) have neurotropic and antitoxic activities. Mono-D-glucosamine salts of alpha-ketoglutaric acid, alpha-keto-carboxyamide-butyric acid, alpha-keto-zeta-aldehyde-valeric acid, pyruvic acid or oxaloacetic acid; di-D-glucosamine salts of alpha-ketoglutaric and oxaloacetic acids; mixed D-glucosamine and sodium salts of alpha-ketoglutaric and oxaloacetic acids. The silver salt is in 40-50% colloidal suspension; the D-glucosamine hydrohalide soln. is 30-35%, and is added dropwise to the suspension, with stirring. The mixture is heated at 45-80 deg.C. If the keto-acid is dicarboxylic, it may be treated with 2 equivs. of glucosamine, or alternatively it may be treated with a 1 equiv. of glucosamine and then 1 equiv. of metal halide (to give R=COOX) or organic halide (pref. ethyl bromide); in the latter case the product is then treated with ethanolic NH3 (to give R=CONH2). After the silver halide has been filtered off the soln. is frozen and freeze-dried, or else concentrated under vacuum. The preferred hydrohalide is D-glucosamine hydrochloride. |
| priorityDate | 1966-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.