http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-525865-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 |
| filingDate | 1968-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d7b9236f77d5a5786090401612b898a |
| publicationDate | 1972-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-525865-A |
| titleOfInvention | Method for purification of 6a-6-deoxy-5-oxytetracycline |
| abstract | The process comprising recrystallizing the impure sulphosalicylate salt of alpha-6-deoxy-5-oxytetracycline (hereafter (A)) contng. metal contaminants and anhydro-and apo -tetracycline compounds from methanolic HCl, dissolving the recryst. (A) salt in dry ethanolic HCl, adjusting the HCl content to at least 12 moles per mole of (A), and adding H2O up to 11 vol.%, to precipitate the hydrochloride salt of (A). Above process wherein (1) recryst. is effected by dissolving (A) salt in dry methanolic HCl, adding 0.25-0.75 vol H2O per vol of solution and at least 0.5 moles (preferably 0.9 to 2.2 moles) sulphosalicylic acid per mole of dissolved (A), whereby recryst. (A) salt separates; (2) in process (1) the dry methanolic HCl contains at least 4% W/V HCl, c 15 ml of this soln. is used for each gm. of (A) salt, resulting soln. is refluxed for 1/2-1 hr. when the impurity is 5alpha,6-anhydro-oxytetracycline; (3) dry ethanolic HCl contains at least 8% W/V HCl; (4) the aq. ethanolic soln. of (A) contains at least 3 vol % H2O, and (5) adjustment of HCl content and addition of H2O are effected simultaneously by adding 0.125-0.75 ml conc. HCl to said soln. per gm. of (A). A high purity hydrochloride of the antibiotic (A) is prepared. It yields clear solutions in water. |
| priorityDate | 1967-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.