abstract |
Imidazole derivs:- - (I) Ar = aryl - R1 = H or alkyl or -(CH2)nX where n = 2-4 and X = halogen, OH or alkoxy - R2 = H, NO2, halogen, carboxamido, SO2NH2, NH2 or alkoxy - R3 = H, alkyl, COOH, aryl, halogen, OH, NH2, alkylamino, dialkylamino, NO2, SO2NH2, alkylsulphonamido, dialkylsulphonamido, alkoxy, alkylthio, CN, carboxamido, alkylcarboxamido, dialkylcarboxamido, formyl, alkanoyl, acylaminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, N'-morpholinoalkyl, N'-piperidinoalkyl, N'-pyrrolidinoalkyl, hydroxyalkyl, alkoxyiminocarbonyl, amidino, alkylamidino, dialkylamidino, carboxyhdrazido, alkoxycarbonyl or alkylsulphonyl. - R4 = H and R5 = NO2 or R4 = NO2 and R5 = H. - Pref. Ar = Ph or naphthyl, R4=NO2, R5 = H - When R1 = H, tautomeric forms. - Antiprotozoals (esp. effective against Histomonas meleagridis and Trichomonas vaginalis). |