http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-520670-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-26 |
| filingDate | 1969-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2609fc8cb25659b7937a3c9310a5b203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e994011aa53f9320b0a7a81a345bba54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91ada43523fc5c925c93cd09f3d8a346 |
| publicationDate | 1972-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-520670-A |
| titleOfInvention | Process for the preparation of 3-indolylacetic acid derivatives and their salts |
| abstract | Low toxicity anti-inflammatory 1-acyl-3-indolylacetates. M3A. Are new compounds of formula:- and their acid addition salts. (R' = styryl, phenyl optionally subst. by halogen or methylenedioxy; R2, R3=H, alkyl (C1-C2); R4= H, halogen, alkyl (C1-C4), alkoxy (C1-C4); A=(CH2)2.0. (CH2)2-, -CnH2n where n= 1 to 6; B-NH2, alkylamino, dialkylamino or a heterocyclic ring (C5-C6) optionally substd. by aralkyl, phenyl, uralkenyl or alkyl, which contains 1 or 2 N atoms). - Used as highly active anti-inflammatory agents with low toxicity, also having antipyretic and analgesic activity. The therapeutic index is higher than that of indomethacin and phenylbutazone, doses of 400 mg/kg orally not giving rise to faecal occult blood in test animals. - Specifically beta-morphlinoethyl 1-cinnamoyl-2-methyl-5-methoxy-3-ind olylacetate hydrochloride is about as active in the rat food oedema test as indomethacin but the latter is more toxic at 10 mg/kg than (I) is at 200 mg/kg. Tests of 6 other compounds (I) are quoted. - Prepared by (a) esterification of corresponding acid and alcohol. |
| priorityDate | 1968-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.