http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-514546-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1967-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d7b9236f77d5a5786090401612b898a |
| publicationDate | 1971-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-514546-A |
| titleOfInvention | Process for the production of x-6-deoxytetracyclines or of x-6-deoxy-5-hydroxy-tetracyclines |
| abstract | Prepn. (claimed) of alpha-6-deoxytetracyclines (I) in which a mixture of 6-deoxy-13-mercapto-5-oxytetracycline (A) or 6-deoxy-13-mercapto-tetracycline (B) (or salts of (A) or (B) (pref. with sulphosalicylic acid), a tri-(lower alkyl) phosphite ((RO)3P) (is not 1 equiv.), and a free-radical-generating catalyst (FRC) (0.1-1.0 pts. by wt./pt. by wt. of (A) or (B)) is heated at 50-150 deg., pref. 100-105 deg. in excess (RO)3P or pref. an inert solvent (THF, EtOH, ethylene glycol monoethyl ether, etc., pref. dioxane). (FRC) may be H2O2, benzoyl peroxide, etc., pref. alpha, alpha-azobisisobutyronitrile (II) (pref. 0.4-0.5 pts. by wt.). (A) and (B) may be prepd. as in US. 3,165,531 and an example is also given in the original. Desulphurization process gives high yields of (I) without need for extensive purificn. of the product (unlike US. 3,165,531, in which desulphurization is effected with Raney Ni, which contaminates the produced (I)). |
| priorityDate | 1966-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.