http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-513889-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cd3ea6c52ef8544c67c051a2ef489b3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 1968-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbaa0c16a7650fd804d4c091e7156596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38ef5cd1675f9a9e2cfd13cf7f05a079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b2afbf6aff0389c7c359df8de0fb9ac |
| publicationDate | 1971-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-513889-A |
| titleOfInvention | Process for the preparation of 1,3,5-triazine derivatives |
| abstract | Improved method for: and salts of (I) where R1, R2, R3 and R4 = H, alkyl, alkenyl, cycloalkyl, aralkyl, and/or aryl, or and/or = an opt. substd. satd. heterocyclic residue, opt. cont. another heteroatom R5 = opt. substd. aryl or pyridyl. Hypotensives and diuretics (q.v. NE.68, 10196) LD50 for (I) (R1 = R2 = Me, R5 = Ph, NR3R4 = morpholino), (i.v. mouse) = 125-500 mg./kg. Biguanide. HCl (3.48 g.) and ethyl phenylmorpholino acetate (5. 1 g.) were refluxed 6 hr. with Na(0.92 g.) in MeOH (15 ml.), evapd. in vac., the residue mixed with H2O, filtered, and recryst. from EtOH, giving (I) (R1 = R2 = H, R5 = Ph, NR3R4 = morpholino), m.p. 236 deg. |
| priorityDate | 1967-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.