| abstract |
(A) 7-Aminocephalosporanic acid derivs. R1 = heterocyclyl with min. 2 hetero-atoms bound to the S-atom of the mercaptoacetyl group by a C-atom directly between 2 hetero atoms R2 = a free- or carboxylic acid-esterified hydroxy group in which ester-O-atoms are opt. replaced by S-atoms; an opt, N-substd. carbamoyloxy group in which the O-atoms are opt. replaced by S; or a quaternary amino group. (B) Salts of (I) including internal salts. (I) have antibacterial activity against Gram-pos. and esp. Gram-neg. bacteria such as penicillin-resistant S. aureus, F. coli, K. pneumoniae, S. Typhosa and B. Proteus. They may be used in the treatment of infections caused by these microorganisms or as feedstuff additives, in the preservation of food or as disinfecting agents. 7-(1-methyl-imidazolyl-2-mercapto-acetylamino)caphalosporanic acid. |