| abstract |
Analgesic 2-benzoyl-indole derivs. Title derivs. of formula (I) and their salts with acids (where one of R1 and R2 is H, Cl, CH2, or OCH3 and the other is H or R1 + R2 is methylenedioxy; R3 and R4 are not >4 C alkyl or NR3R4 is 1-pyrrolidinyl or piperidino; R5 is H, Cl, CH3 or is not >3 C alkoxy; and R6 is not >3C alk(en or yn)yl linked through a satd. C atom), which have tranquillizing, antianaphylactic, anti-oedema and esp. analgesic activity with relatively low toxicity, are prepd. by reacting a corr. 2-benzoyl-3-(2-Z-ethoxy)-indole (where Z is halogen or lower alkane- or arenesulphonyloxy) with HNR3R4. |