http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-508649-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-26 |
| filingDate | 1968-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c786a91e466b5bc4dca4b6d6dd374ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b16a1e2cc24bf7dba7672d2697482b28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b1e463f049d1fa7a0b568b2dd20a866 |
| publicationDate | 1971-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-508649-A |
| titleOfInvention | Process for the preparation of 5,6,7,8-tetrahydro (1) benzothieno (2,3-d) pyrimidines |
| abstract | New pyrimidine derivates and their manufacture. G3A. Novel compounds of the formula (I) and their addition salts:- (where R = OH, halogen or opt. substd. amino lower alkylamino amino and ring A must be substd. by at least one carbocyclic aromatic group) which have antibacterial, antiparasitic and antiinflammatory activity may be prepared by reacting an aryl substd. 2-mercapto cyclohexanone or 5(6) hexenone with cyanoacetic acid or its deriv. to give 1-mercapto-2-cyanoacarboxymethylene cyclohexane (or 5(6)ene) which is cyclised to novel 2-amino-3-carboxy-6,7-dihydro and 4,5,6,7-tetrahydro benzo b thiophenes with antiphlogistic and hypotensive activity, which are converted to (I). In an example, 4-chloro-6,8-diphenyl-5,6,7,8-tetrahydro- 1 -benzothieno pyrimidi- ne is reacted with beta-diethylaminoethylamine to give 4-(beta-diethylaminoethylamino)-6,8-diphenyl-5,6,7,8-tetrahydro- - 1 -benzothieno(2,3-d pyrimidine. are then converted to (I) (R = OH). This converted to (I) (R = halogen) and then to (I) (R = aminoalkylamino). |
| priorityDate | 1968-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 180.