http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-508643-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 1968-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cb885d0a7132fbd9ca09279572aecf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_570a80e785369cd50ae68dbf91770e17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_628406cf954f3a83226f0e6a5254fafc |
| publicationDate | 1971-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-508643-A |
| titleOfInvention | Process for the production of phthalimidine derivatives |
| abstract | Phthalimidine derivs. of general formula (I) - R1 = H, 1-6C alkyl/alkenyl opt. substd. by OH or SH, free or esterified or etherified, amino, COOH, halogen; aralkyl, cycloalkyl or aryl opt. substd. - m, n = 0-2 - m+n = 1 or 2 - As tumour-inhibitors and immunosuppressants. - (a) A soln. of alpha-phthalimidoglutaric acid (133 g) in AcOH (1.2 l) at 60 deg. is treated gradually with Zn dust (168 g.) and the mixt. then refluxed for 4 hrs. to give alpha-phthalmidinoglutaric acid (70%), m.p. 236-7 deg. (water). - (b) this (108 g), Ac2O (833 ml) and SOCl2 (29.7 ml) are refluxed to give the anhydride (90%). m.p. 254-7 deg. dec. - (c) this (2.45 g.) and urea (0.3 g) are heated at 180 deg. for 90 mins. to give 3-phthalimidinopiperidine-2,6-dione, m.p.240-2.5 deg. (AcOH). |
| priorityDate | 1967-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.