| abstract |
Cpds. of general formulae (I) and (II) and pharmaceutical compns. contg. them. where R=H, hydrocarbyl opt. substd. by is not > 6F, Cl or Br and/or at least 1 group chosen from; OH, NH2, HO/amino-hydrocarbyl (hydrocarbyl chain may contain O or N)and/or substd. by: OH, NH2, COOH COOM (M=alkali or alk. earth metal), F, Cl, Br. X=R, -COR, -COOR; but R + X do not contain >30 C Z's = H, F. Espec. the cpds. in which: R = H, X=C(CF3)2NH2, H, CH2OH, CH2NMe2, CH2OCH2OH, Z's = F R=H;X=CF(CF2H)NH2, H, Z=Z2=F Z1=Z3=H R=Et, X=H, Z's=F. The cpds. are CNS-depressants. Useful in treating neurological and psychiatric disorders and in obtaining relaxation under general anaesthesia. |