http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-503733-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D203-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-46 |
| filingDate | 1968-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4da7ae2baf2551f6d2e14c24e1771de5 |
| publicationDate | 1971-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-503733-A |
| titleOfInvention | Process for the preparation of new derivatives of sulfanilamide |
| abstract | (A) Cpds. of general formula (I) R' = (1-5C) alkyl, (2-5C) alkenyl, (is not > 7C) cycloalkyl, or (is not > 7C) cycloalkenyl R2 = Me or Et (B) Acid addn. salts of I. Oral and parenteral hypoglycaemics. Dose. 100-500 mg/d. (a) N'-(1-methyl-2-t.butylaminoethyl)-N4-acetyl-sulphanilamide (32.7 g.) was dissolved in 2N-NaOH (100 ml), BrCN (10.6 g.) added at 20-30 deg., stirred 30 mins., filtered, and recryst. from DMF, giving the acetanilide, m.p.243-4 deg. (b) This (35.2 g.) was added to 50% H2SO4 (125 g.) at 40 deg., stirred 2 h. at 50 deg., poured into H2O (750 ml), 10N-NaOH added to pH 6.3, stirred 15 mins. with charcoal (2 g.), filtered (Hyflo), basified (10N-NaOH), filtered, washed, dried, and recryst. from EtOAc, giving I, m.p.145-6 deg. |
| priorityDate | 1968-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.