http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-503036-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bfedd8ba4800708cecfd357707f8f67 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1968-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fbc61e731b9cd688b94c54f17ed0350 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a6d8956dbdf677de6db238417f573e5 |
| publicationDate | 1971-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-503036-A |
| titleOfInvention | Process for the preparation of cytostatically active 5'-deoxy-5'-fluorine-substituted 2'-deoxyribonucleosides |
| abstract | R = H, Ac P = purine or pyrimidine residue, e.g. 1-thyminyl 1-uracilyl, 1-(5-halouracilyl), 1-cytidyl, 9-adenyl or 9-guanyl The cpds. are cytostatically active, e.g. against Ehrlich ascites tumour cells in vitro. 2'-Desoxyribonucleosides contg. 5'-arylsulphonyl or 5'-mesyl radicals, & opt. acetylated, are treated with an alkali fluoride for 15 min. -5 hr. (pref. 1/2-2 hr) in a solvent such as acetamide, dimethylacetamide, glycol or MeOH, at 50-160 deg. (pref. 130-150 deg.) & the product purified by chromatography. |
| priorityDate | 1967-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.