http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-500491-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-556 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0284 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-556 |
| filingDate | 1968-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a24a7eec378bfe089ca43824c38a66b |
| publicationDate | 1970-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-500491-A |
| titleOfInvention | Process for obtaining a stable, sensitized preparation of erythrocytes |
| abstract | Process for preparing stabilised erythrocyte prepns. (I), wherein blood (e.g. from rabbit, rat, dove, sheep, chicken, man, etc.) is mixed with an isotonic anti-coagulant, centrifuged, and the erythrocytes washed with neutral buffer. They are then suspended in neutral buffer (>10 vols.), treated with propan-1-al-2-one (1 vol.) overnight, washed, resuspended, treated with formalin (1 vol) and again washed. The erythrocytes may then be stored for a long time below 4 deg. without agglutinating or haemolysing spontaneously. This treatment has no noticeable effect on the normal immunological properties of the erythrocytes. - The erythrocytes may also be activated by treating with suitable antigens, pref. 1-24 hrs. at 24 deg. and pH3.6-7-0. Both activation and stability are improved by cooling to - 190 deg., and storing subsequently at -20 deg. for 16 weeks, by cycling for 6 weeks from -20 deg. (6-7 days) to +24 deg. (a few hrs.), or by treatment with NaIO4. Alternatively, activation may be carried out by fibrinogen treatment. The products can be stored at -190 deg. or freeze dried, until required. - Haemagglutination tests for detection and determination of gamma-globulins, bacterial and virus infections, histocompatability, auto immune diseases, and for assay of antigens. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2449893-A1 |
| priorityDate | 1967-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.