http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-494208-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-068 |
| filingDate | 1967-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19905f71624910f85d7433c5dfb0feb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bff2ea31b41ba6ccda8d4b6f83e4b7b |
| publicationDate | 1970-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CH-494208-A |
| titleOfInvention | Process for the preparation of N- (L-Lysyl-L-arginyl) -N ', N'-bis (2-chloroethyl) -p-phenylenediamine |
| abstract | N-(L-lysyl-L-arginyl)-N', N'-bis(2-chlorethyl)-p-phenylene diamine (I) and its salts have outstanding cyostatic properties in vivo at low toxicity and are useful for treating malignant tumours and sarcomae. (I) is prepared by acylating L-arginyl-N, N-bis(2-chlorethyl)-p-phenylene diamine with an activated deriv. of an acid R-NH-C(R-HN-(CH2)4)H-COOH (where R are masking groups for blocking the alpha - and epsilon -amino groups of the lysine group) and separating the masking groups by acidolysis or hydrogenolysis, (I) is opt. converted to acid addition salts. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0038357-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0038357-A1 |
| priorityDate | 1967-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.