| abstract |
The invention relates to an isolated proteinaceous particle comprising a core of perforin and/or granzyme, the core being surrounded by a glycoprotein shell comprising thrombospondin- 1 (TSP-1) or a fragment thereof, a variant thereof or an orthologue thereof. The invention further relates to nn engineered proteinaceous particle comprising a core of perforin and/or granzyme, the core being surrounded by a glycoprotein shell comprising a thrombospondin protein, or a fragment thereof, a variant thereof or an orthologue thereof, wherein the granzyme and/or the thrombospondin is genetically modified. Further related materials, medical uses and manufacture are also contemplated. |